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All potential phosphorylation sites in a protein are phosphorylated upon protein activation. True or False?

All potential phosphorylation sites in a protein are phosphorylated upon protein activation.

True or False?

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Answer #1

The answer is false.

The protein activation by phosphorylation is one of the pathway which accounts for 20-50% in different organism. Here phosphate is transferred to the site by protein kinase to produce phosphoprotein. This phosphorylation changes the structural confirmation of the protein and hence its activity.

So there are protein which get phosphorylation at different sites at different time to perform specific function due to different protein confirmation .

Hence all potential sites are not phosphorylated upon protein activation.

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