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True or False: If a protein has a signal sequence for synthesis into the ER, but...

  1. True or False: If a protein has a signal sequence for synthesis into the ER, but the sequence is NOT at the N-terminal, then after synthesis the N-terminal will either be in the lumen or outside the cell
    1. If false, where would the protein be?
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Answer #1

protein has signal sequence and the signal sequence is not at the N terminus, once the signal sequence is translated the Signal recognition particle (SRP) binds to it and then SRP binds SRP receptor on the ER membrane and then mRNA-peptide ribosome complex is loaded to the translocon in the ER membrane, the signal sequence will be inserted into the ER lumen.

the arrangement of a protein on the ER membrane with internal signal sequence is

so N terminus is on the cytosolic region.

so the given statement is False.

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