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True or False- Gut specific chemokines enable T cells to return to the gut after activation...

True or False- Gut specific chemokines enable T cells to return to the gut after activation in mesenteric lymph nodes.

True

False

(immunology)

Science   Biology   
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Answer #1

True.

Gut-specific homing is the mechanism by which activated T cells and antibody-secreting cells (ASCs) are targeted to both inflamed and non-inflamed regions of the gut in order to provide an effective immune response. This process relies on the key interaction between the integrin α4β7 and the addressin MadCAM-1 on the surfaces of the appropriate cells. Additionally, this interaction is strengthened by the presence of CCR9, a chemokine receptor, which interacts with TECK. Vitamin A-derived retinoic acid regulates the expression of these cell surface proteins.

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