Etanercept is a dimeric fusion protein, composed of the extracellular domain of the TNF-α receptor and the Fc portion of human IgG1.Etanercept is a biologic tumor necrosis factor (TNF) inhibitor. the drug acts as a soluble TNF receptor and binds TNF-alpha and TNF-beta.
TNF is a cytokine that can bind to TNF receptor 1 (TNFR1) or TNF receptor 2 (TNFR2) and is involved in inflammation and the immune response. When TNF binds to TNFR1 or TNFR2, it activates important inflammatory pathways, such as NFkB and MAPK. The structure of Etanercept consists of two p75 TNF receptors fused to the Fc portion of human IgG. Etanercept works by blocking the effects of TNF-alpha, a pro-inflammatory cytokine that becomes elevated in psoriasis, rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, and ankylosing spondylitis.
Get Answers For Free
Most questions answered within 1 hours.