Question

what is the mechanism of action for Glucocorticoids in the treatment of psoriasis ( the aniinflammatory...

what is the mechanism of action for Glucocorticoids in the treatment of psoriasis ( the aniinflammatory and metabolic mechanism )

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Answer #1

Psoriasis is the skin disorder that causes skin cells to multiply up to 10 times faster than normal. This results in the skin build up into bumpy red patches covered with white scales.

The pathophysiology of psoriasis is multifactorial. It involves epidermal hyperproliferation, abnormal differentiation of epidermal keratinocytes, and inflammation with immunologic alterations in the skin.

Topical glucocorticoids normalize epidermal differentiation and suppress inflammatory responses.

It reduces the inflammations, prevents the abnormal epidermal proliferation and differentiation of keratinocytes.

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