Question

5. Mechanism of action of Lantus

a. Binds to serum proteins and is slowly released

b. Insulin hexamers and dimers bind 300 times weaker, peak levels are sooner than with regular insulin

c. Insulin precipitates into crystals and is slowly absorbed over 24 hours

d. Human insulin that binds to albumin via a fatty acid linkage

Answer 1

LANTUS (insulin glargine [rDNA origin] injection) is a sterile solution of insulin glargine for use as an injection. Insulin glargine is a recombinant human insulin analog that is a long-acting (up to 24-hour duration of action), parenteral blood-glucose-lowering agent. The primary activity of insulin, including insulin glargine, is regulation of glucose metabolism

Insulin glargine is a human insulin analog that has been completely soluble. After injection into the subcutaneous tissue, small amounts of insulin glargine are slowly released over 24 hours. The action of insulin detemir is prolonged by the addition of a fatty acid side chain that promotes reversible binding with albumin in the interstitial fluid and in the circulation.

Correct option: d. Human insulin that binds to albumin via a fatty acid linkage.