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16. Phosphorylation can be used to either inactivate or activate enzymes. How this phenomenon regulates glycolysis?

16. Phosphorylation can be used to either inactivate or activate enzymes. How this phenomenon regulates glycolysis?

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Glucose‐6‐phosphate formation. The entry point of glucose is the formation of glucose‐6‐phosphate. Hexokinase is feedback‐inhibited by its product, so the phosphorylation of glucose is inhibited if there is a buildup of glucose‐6‐ phosphate. In mammalian cells, the breakdown of glycogen is regulated by covalent modification of glycogen phosphorylase. This regulation reduces the rate of formation of glucose‐6‐phosphate.

The phosphorylation of glucose can be enhanced by the binding of Fructose-6-phosphate, and lessened by the binding fructose-1-phosphate.

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