Question

16. Which of the following is NOT true about enzymes?

A) Some enzymes require cofactors.

B) Enzyme inhibitors may interact either reversibly or irreversibly with an enzyme to alter its Km and /or Vmax values.

C) Transition state stabilization can significantly increase the activation energy for a reaction.

D) Enzymes typically act under milder conditions of temperature and pH than (nonenzyme) chemical catalysts.

E) Zymogens are a form of inactive precursors of enzyme.

Answer 1

The correct answer is C. Transition state stabilization can significantly increase the activation energy for a reaction. The enzymes act like catalyst by lowering the activation of energy by stabilizing the transition state. The enzymes form an active site of the shape of transition state of reaction and bind to it. This stabilize the transition state and leads to decrease in activation energy and catalyse the reaction. Thus enzyme decrease activation energy inspite of increasing it.

All other option are absolutely correct.

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