The phosphorylation is responsible for activation and deactivation of protein . The phosphorylation can alter the structure of protein . The neuratrans mitten and hormones in the cell signaling regulates the stimulation of protein through the phosphorylation . The protein kinase is responsible for the phosphorylation of the protein . The phosphorylation is also responsible to the generation of cyclic AMP in the case of secondary messenger . In the brain , the extracellular signaling is also regulated by the activity of kinase and phosphatase. The GTP binding proteins acts on the signaling machinary or the pathway and regulates the function of protein . The protein becomes active when they bind with GTP and inactive when they bind with GDP .Thanking you
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