Question

Provide details in words including names of structures, enzymes, cofactors, etc. for how the product of glycolysis is converted into the two-carbon precursor for fatty acid synthesis AND how this two-carbon precursor is moved into the correct cellular location. Following fatty acid synthesis, fatty acids are moved into either membrane lipids or triacylglycerols. Beginning with phosphatidic acid, explain the pathway including names of structures, enzymes, cofactors, etc. for the synthesis of a glycerophospholipid. What is the enzyme that catalyzes the rate-determining step during fatty acid synthesis, and explain one way that enzyme is regulated?

Excess dietary carbohydrates are stored in the body. Once glucogen storage is full, carvohydrates are converted into fat for starage.

Answer 1

in fatty acid synthesis, acetyl-coA is the direct precursor only of the methyl end of the growing fattyacid chain. all the other carbons come from the acetyl group of acetyl-coA byt only after it is modified to provide the actual substrate for fatty acid synthese, malonyl-coA.they are drive by the release of CO2.

ENZYMES: acetyl coA which catalyze synthesis of malonyl-coA, is only regulated enzyme in fatty acid synthesis. its regulation involve both allosteric control and covalent modification. AMP kinese and protein Kinese for phosphorylation. palmitoyl-coA,it is necessary for remain catalytic reaction. fatty acid synthase complex, it is a poypeptide containing seven enzyme activities.

COFACTER AND COENZYMES ARE: biotin, NADPH,Mn++, Mg++