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What is the role of the phosphates added to either end of the glucose molecule?  Which enzymes...

What is the role of the phosphates added to either end of the glucose molecule?  Which enzymes are irreversible and serve as control points to regulate the amount of glycolysis occurring?  How are they regulated?  And is it different in different tissues?  What is the overall ΔG going from glucose to pyruvate?

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Explanation:-In glycolysis enzymes catalyzing irreversible reactions are main control sites. In glycolysis, enzymes such as hexokinase, phosphofructokinase, and pyruvate kinase catalyse irreversible reactions. Hexokimase is inhibited by high levels of glucose 6 phosphate. Phosphofruktokinase is irreversible inhibited by high ATP concentration Phosphorylation of glucose in glycolysis prevents glucose from being leaked or diffused out of cell. The overall free energy change from glucose to pyruvate is 20kcal/mol.

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