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What can you predict about the location of core promoter sequences and polyadenylation cut sites in...

What can you predict about the location of core promoter sequences and polyadenylation cut sites in the genomic sequence of a gene with multiple transcription start and termination sites?

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Answer #1

Core promoters for multiple transcription start site are located between two distinct regions of DNA ; CpG islands and ATG deserts.

CpG island is a stretch of DNA rich in CpG dinucleotide , which is a methyl transferase substrate.

ATG desert is the region of DNA which has a lower occurance of ATG trinucleotode than surrounding sequence and are responsible for use of multiple, dispersed transcription start site, so, permitting the core promoter to serve as a platform where complex upstream regulatory signals are integrated.

For multiple transcription termination site, Poly A site cut site choice is regulated mainly by core RNA 3ʹ end processing factors :

cleavage factor I

cleavage & polyadenylation specificity factor,

other RNA-binding proteins, particularly splicing factors

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