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Are the following genes either an oncogene or tumor suppressor gene? ARID1A ATM BRAF

Are the following genes either an oncogene or tumor suppressor gene?

ARID1A

ATM

BRAF

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Answer #1

ARID1A: AT rich interactive domain-containing protein 1A is a protein encoded by ARID1A gene. It is a tumor suppressor gene that regulates gene expression by controlling gene accessibility. This gene is invovled in breast and ovarian cancer.

ATM: ATM gene is a serine / threonine protein kinase that phosphorylates the various other proteins involved in DNA damage repair. ATM gene is recruited by double stranded breaks in the DNA. The ATM gene targets the tumor suppressor genes like p53, CHK2, BRCA1, NBS1 and H2AX etc.

BRAF: BRAF is gene encoding a protein called B-Raf. This gene is a proto-oncogene B -raf and its protein is previously known as serine/threonine-protein kinase B-Raf. This gene regulates the MAP kinase/ERK signaling pathway, affecting the cell division, differentiation, and secretion.

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