It is true to say of Proto-oncogenes and Tumor Suppressor Genes that
A. |
Proto-oncogenes are typically "activated" into an oncogenic state. |
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B. |
Tumor suppressor genes increase cell division rates when functioning properly |
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C. |
Tumor suppressor genes are typically "activated" into a tumor-producing state |
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D. |
Oncogenes are genes that ought to be expressed but have been turned off or "deactivated" |
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E. |
Tumor suppressor genes are activated proto-oncogenes |
Answer: (A) Proto-oncogenes are commonly activated in transformed cells by point mutations or gene amplification.
Explanation: A proto-oncogene is a gene with normal function, that can convert into a cancer-causing oncogene through mutations or amplified expressions.
Other options are incorrect because:
(B) Tumour suppressor genes normally keep a check on rampant proliferation of cells, thereby preventing cancer
(C) In cancerous cells, the tumour suppressor genes get inactivated and hence cancer is caused
(D) Oncogenes are ought to remain unexpressed since they code for certain proteins that can transform a healthy cell into a cancerous cell
(E) Tumour suppressor genes are completely different set of genes and are not genomically related to proto-oncogenes.
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