Question

How does a renal tumor that obstructs the basolateral membrane of the proximal tubule effect proximal tubule reabsorption?

Answer 1

Proximal convoluted tubule forms a basolateral membrane for the reabsorption of fluid and electrolyte from the filtrate into the peritubular capillary. So when a tumor is present in this area it will result in the occulution of the sodium potassium ATP ase that cause the absorption of sodium into the peritubular capillary and this helps in the reabsorption of water into peritubular capillary. So when the sodium is not reabsorbed due to tumor fluid loss also will occur as reabsorption of water will reduce