Question

Josh is studying secretion of organic anions in the proximal tubule of the nephron. He has isolated proximal tubule cells and performed various experiments. Which of the following finding is likely to be accurate? Choose the best answer:

(a) When Josh inhibits Na⁺-dicarboxylate cotransporter (NaDC) on the apical and basolateral membranes of the proximal tubule cells, the rate of organic anion secretion is increased

(b) When Josh inhibits ATP synthesis in the proximal tubule cells, the rate of organic anion secretion is not affected

(c) When Josh increases the intracellular concentration of Na⁺ in proximal tubule cells, the rate of organic anion secretion decreases

(d) When Josh increases the rate of synthesis of organic anion transporters, the rate of organic anion secretion is not affected

Answer 1