Question

questions is related to pharmacology you can answer in your own opinion

6. How can adsorption affect free concentration of the drug?

5. Why might drug concentration in the blood not be equivalent to the drug concentration at the receptor site?

Answer 1

6) The most common mechanism of absorption for pills is passive diffusion. This system can be explained through the Fick law of diffusion in which the drug molecule strikes according to the concentration gradient from a greater drug awareness to decrease concentration until equilibrium is reached. Passive diffusion can appear in an aqueous or lipid environment.

5) A drug’s effect is often related to its concentration at the site of action, so it would be useful to monitor thisconcentration. Receptor sites of drugs are generally inaccessible to our observations or are widely distributed inthe body, and therefore direct measurement of drug concentrations at these sites is not practical. For example, the receptor sites for digoxin are thought to be within the myocardium. Obviously we cannot directly sample drug concentration in this tissue. However, we can measure drug concentration in the blood or plasma, urine, saliva, and other easily sampled fluids . Kinetic homogeneity describes the predictable relationship between plasma drug concentration and concentration at the receptor site where a given drug produces its therapeutic effect . Changes in the plasma drug concentration reflect changes in drug concentrations at the receptor site, as well as in other tissues. As the concentration of drug in plasma increases, the concentration of drug in most tissues will increase proportionally.

Similarly, if the plasma concentration of a drug is decreasing, the concentration in tissues will also decrease