Question

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6. Describe a dose-response curve and explain the significance of certain features of the dose response curve like the threshold, slope and maximal asymptote. How does this curve relate to potency and maximal response of drug?

Answer 1

Dose is the amount of drug to Administer to produce a certain degrees of response in a patient. Dose response relationship has two components

1. Dose-plasma concentration relationship
2. Plasma concentration-response relationship

Response: The change in activity of the cell or tissue produced by the selected dose of the drug is called the response.The dose and response is closely related to each other and this relationship is called as Dose response relationship ie.the intensity of response increases with the increase in dose.

Relationship of dose to response can be illustrated by a graph which is called as dose response curve.

Threshold is a dose below which there are no adverse effects from exposure to chemicals.

Slope is the effect of incremental increase in dose.

Asymptote is line whose distance to a given curve tends to zero.An asymptote May or may not intersect its associated curve.

Drug potency is the amount of drug needed to produce a response and drug efficacy or maximal response is the ability of drug to elicit a response when it binds to a receptor.