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What the role of cGMP-dependent ion channel in the phototransduction?

What the role of cGMP-dependent ion channel in the phototransduction?

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Answer #1

Rhodopsin light perceving pigment present in rod cells , it is made of protein called as opsin and a chromophore as 11 cis retinal.

on perceving light cis retinal converts into trans retinal and rhodopsin gets activated , activated rhodopsin activates a G protein known as transducin which activates a membrane bound enzyme C GMP .

C-GMP converts cyclic GMP into 5' GMP that leads to closure of CGMP induced sodium ion channel which further closes sodium ion induced calcium ion channel.

In the presence of loght rod cells membrane becomes slightly hyperpolarized.

during darkness activity of guananylyl cyclase activity increases the level of CGMP leading to opening of sodium and calcium ion channel.

light ----> Rhodopsin -----> transducin ----->CGMP to 5'GMP ----> closure of Na+ which results in the closure of calcium ion channels.

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