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What differences did you notice between the point mutation and the frameshift mutations?

What differences did you notice between the point mutation and the frameshift mutations?

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Point mutation or simple mutation or substitution mutation results from the substitution of one base pair for another or one base for another in case of single stranded DNA genomes. It may be a transition or a transversion.Transition is the most common class in which one pyrimidine is substituted by the other or one purine is substituted by other.

One example of point mutation is that in ras protooncogene which is converted into an oncogene leading to malignancy.

A point mutation does not change the frame of translation.

A frameshift mutation is one in which there is addition or deletion of a base pair. If this occurs with protein coding portion of Gene, it will shift the translational frame. Frameshift mutations can result in triplet repeat expansion disorders.

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