Question

A point mutation occurs in the middle of the coding sequence for a gene. Which types of mutations-silent, missense, nonsenese, and frameshift- would most likely dirupt protein function and which would be most likely?

Answer 1

Silent mutation is change in mutation in third position of codon such that amino acid does not change. So, it doesn't affect the protein.

Missemse mutation changes one amino acid but that won't disrupt the protein function.

Nonsense mutation changes amino acid codon into stop codon and protein is not made. So, this will definitely disrupt the protein function and structure.

Frameshift mutation is insertion or deletion of nucleotide in gene such that the whole codon frame is changed and different protein is made. This will also disrupt the protein function.

Nonsense mutation would be most likely to disrupt the protein function because of the stop codon that makes truncated protein.