Question

Classify the mutations below as transition, transversion, or indel mutations.

1. TGCAATGCC -> TGCAGTGCC

2. TGCAATGCC -> TTCAATGCC

3. TGCAATGC ->TGCAAT

Can any of the mutations above be classified as point mutations?

Can any of the mutations above be classified as missense mutations?

Can any of the mutations above be classified as nonsense mutations?

Can any of the mutations above be classified as a frameshift mutation?

Answer 1

1)Transition mutation (Purine changed with purine,pyrimidine change with pyrimidine. Transversion mutation(two rings of purine replace with one ring of pyrimidine and vice versa). These both are a type of point mutation.

2)Transition mutation act as a missense mutation(change of one DNA base pair that results in substitution of one amino acid with another amino acid).

3)Indel mutation(deletion and insertion of nucleotides) act as nonsense mutation.

4)Indel mutation is may be as a frameshift mutation (addition and deletion of base pairs).