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What is the role of the Human papilloma virus genes E5 E6 and E7 in cancer?

What is the role of the Human papilloma virus genes E5 E6 and E7 in cancer?

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E5 of HR HPV by itself can induce morphological and chromosomal changes that frequently accompany the progression of normal cells to cancerous cells. Increased nuclear size, increased DNA content and tetraploidy.

The viral E6 and E7 oncoproteins are necessary for malignant conversion. The abilities of high-risk HPV E6 and E7 proteins to associate with the tumour suppressors p53 and pRB, respectively, have been suggested as a mechanism by which these viral proteins induce tumours.

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