Question

Explain the relationship between sequence, structure, and function in terms of amino acid sequence.

Answer 1

Sequence of a protein largely dictates the structure. Hydrophobic residues are buried in the interior of the protein while hydrophilic residues are exposed. The residues required for binding the substrate should have their charged groups exposed and accessible. Such phenomena impose restrictions on the protein fold, thus defining its structure. Function is supported by the structure and sequence. For example, a dehydrogenase should have the Rossmann fold in the structure. Function can be brought about only by the presence of the requisite residues placed correctly in the structure.