Question

What are 2 host proteins that the stalk part of the antibody bind to?

Answer 1

2 host proteins are protein A and protein G.

Both the proteins Protein G and Protein A is being isolated from the bacteria. And due to the antibody - binding property of protein A and G,they are being used.

Two important surface gycoproteins in influenza virus are HA and neuraminidase (NA). During immune evasion the immunodominat head domain of HA(which is a trimeric protein) is being mutated . The three helical bundles constitute the HA stalk domain. This is required functionally to induce the conformational changes for the pH induced that is involved in the fusion membrane. This takes place when the viral entry takes place and when it exits the host cell.

The NA allows the viral spread by tethering to release virions that are new and is done for cleaving the HA-sialic acid.The NA which has the ability to block NA cleavage are identified as potentially protective reactive-NA antibodies.