Question

What is the mechanism of action (Enzyme inhibitor, receptor blocker, etc.) for marabal (mephobarbital)?

Answer 1

Mephobarbital

mechanisam of Action

mephobarbital is an irreversible inhibitor of Enzyme GABA transaminase.

Substance that do not act as agonist or antagonist but do not affect the gamma aminobutyric acid receptor ionosphere

molecular formula - c13 H 14 N2 O3

mebaral exerts a strong sedative anticonvulsant action but has a relatively mild hipnotic effects. It reduce the incidence of epileptic seizures in grand mal and Petty mal . It usually cause little or no drowsiness or lassitude.

It is a methyl derivative of phenobarbitone used in the treatment of epilepsy and as a sedative

contraindications- liver disease, porphyria, severe respiratory diseases, barbiturates sensitivity.

Caution- reduce dose in hepatic or renal impairment.

Methyphenobarbital bonds at distinct binding site associated with a Cl- ionopore at the GABA receptor, increasing the duration of time for which the Cl- ionopore is Open . The post synaptic inhibitory effects of GABA in the thalamus is , therefore, prolonged.