Question

Explain in detail the composition and mechanism of how endostatin acts as an inhibitor of angiogenesis. What kind of inhibitor is it? 10 points at least 10lines

Answer 1

Answer. Endostatin - endostatin is produced by different type of cells like, platelets, endothelial cells and tumor cells.

Composition - it is a 20 kDa carboxylic terminal fragment obtained from XVIII collagen.

Mechanism of action - it inhibits cell proliferation, migration and gets endothelial cell apoptosis and arrest cell cycle. It is a anti-angiogenesis drug it means its inhibit vascular endothelial growth factor (VEGF) by tyrosine phosphorylation of KDR /F1k-1, thecell surface receptor of VEGF. VEGF is an important mediator of angiogenesis. Angiogenesis is needed to support the growth of a tumor by supplying oxygen and nutrients to the proliferating tumor cells.

Endostatin also block the activation of extracellular signal related kinases, ERK, p38 mitogen activated protein kinases (MAPKs)