Question

What are the equation/s used in reaching a specific plasma drug concentration using Steady State pharmacokinetics?

Answer 1

t 1/2 = 0,693•Vd/CL

where Vd is the volume of distribution at the steady-state, and CL is the clearance.

Vd = Q/[P]

where Q is the amount of drug present in the body; [P] is the plasma concentration of the drug.

Vd = D/C0

where D is the dose and C0 the concentration at time 0.

LD = SSC•Vd/B

LD is the loading dose

MD = SSC•CL•DI/B

MD is the maintenance dose, SSC the desired steady-state concentration of the drug; B the bioavailability of the drug; DI the dosing interval

CL = drug elimination rate/[P]

K0 = CL•SSC. .

AR = 1 dose/FD.