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If a dose of 50mg of drug A result in a plasma concentration of 0.1 mg...

If a dose of 50mg of drug A result in a plasma concentration of 0.1 mg per liter. What is the volume of distribution of drug A?
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Answer #1

Following equation can be applied:

                    D

         Vd = -------

                  C (0)

D = dose (50mg)

C (0) = extrapolated plasma concentration at time 0 (0.1 mg)

Calculation:

                   50

         Vd = ------- = 500

                  0.1

Therefore, Volume distribution = 500

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