Question

explain how an adjustment in dose and dosing frequency is required for different types of metabolisers

Answer 1

Ans) Since the liver is the principal organ for drug metabolism, a decrease rate of drug metabolism occurs in patients with chronic liver disease, such as hepatitis, or elderly patient with decrease liver function due to aging. In these patients drug doses/frequency need to be reduced to compensate for the prolonged action of unmetabolized drug in the blood and to prevent toxicity from high levels or drug. the liver often makes fat soluble drugs water soluble so they can be eliminated by the kidneys. Premature infants have very immature livers that are unable to metabolize drugs efficiently. the doses of their drugs must be carefully calculated to avoid toxicity.