Question

Polymerase slippage during replication can lead to ( )

A. Deletion of bases

B. Insertion of bases

C. Repeat expansion

D. Substitution of base

Answer 1

ANS) Polymerase slipage during replication can lead to

C) REPEAT EXPANSION

Repeat expansion is a mutation that leads to either a trinucleotide or dinucleotide expansion or contraction in the course of dna replication. A slippage event generally takes place whilst a sequence of repetitive nucleotides (tandem repeats) are discovered on the site of replication. tandem repeats are volatile areas of the genome where frequent insertions and deletions of nucleotides can take vicinity, resulting in genome rearrangements. DNA polymerase, the main enzyme to catalyze the polymerization of loose deoxyribonucleotides right into a newly forming dna strand, performs a big position within the incidence of this mutation. while dna polymerase encounters a right away repeat, it could undergo a replication slippage.