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why does fructose 1,6-biphosphate bind to pyruvate kinase? What is this called?

why does fructose 1,6-biphosphate bind to pyruvate kinase? What is this called?

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Answer #1

Pyruvate kinase activity is most broadly regulated by allosteric effectors. The most significant pyruvate kinase regulator is fructose-1,6-bisphosphate which serves as an allosteric effector for the enzyme.

Allosteric regulation is the binding of an effector to a site on the protein other than the active site, causing a conformational change and altering the activity of that given protein or enzyme. Pyruvate kinase has been found to be allosterically activated by fructose 1,6 bisphosphate.

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