Some limitations in a confirmatory test in molecular diagnostics
to diagnose a disease are:
- Chances of an inherent health risk to laboratory workers when
they perform direct tests on unknown or highly infectious
agents.
- Molecular diagnostic tests can produce false results ranging
false-positive to false-negative.
- The setup for these tests are expensive. Costs are increased in
comparison to traditional tests.
- It is difficult to store the samples after collection at
varying degrees of temperature for future references.
- Any novel/unknown pathogen can contaminate laboratory
equipments and reagents.
- There may be difficulties in validation of these molecular
diagnostic tests.
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