Question

Many prokaryotic and eukaryotic translation factors have a domain in common which is not involved in binding to RNA or the ribosome.  What might the function of this domain be?

Answer 1

Most of these eukaryotic and prokaryotic specific domains are known to possess an alpha-helical structure, which suggests that such domains are easier to invent in the course of evolution. The function of these domains might be is one of the central adapters in the regulation, translation, and degradation, of which NIC is the core conserved portion has accreted several additional distinct predicted domains was accompanied by the acquisition of new regulatory interactions. This suggests a regulatory function for the NIC domain, mediated by specific protein-protein interaction. Mutations in eIF3 subunit PRT1 affecting nuclear processing and transport to perform a regulatory function. This supports the mobility of evolution probably driven by the emergence of additional functions in eIF2beta and other regulatory interactions such as those with the MNK1 kinase.