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2. Describe a scenario where it would be advantageous to use a structural domain analysis tool...

2. Describe a scenario where it would be advantageous to use a structural domain analysis tool over a sequence domain analysis tool, and vice versa. For the former scenario, briefly describe the differences between SCOP and CATH and how these differences may affect whether you use one tool over the other.

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Answer #1

The SCOP which stands for Structural classification of proteins database organizes proteins hierarchically according to their structures and evolutionary origin. It constructs the protein classification through visual inspection and comparison of structures using automated procedures.

CATH which stands for Class, Architecture, Topology, Homologous superfamily is quite similar to SCOP. In the CATH hierarchy, protein domains with very similar structures, sequences, and functions are grouped into sequence families.

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