CD4 cells are white blood cells(lymphocytes) which involved in
important role in the body immune system stimulates other immune
cells such as macrophages, CD8 T lymphocytes, to fight infection.
HIV weakens the immune system by destroying CD4 cells
HIV causes AIDS which depletes the CD4 lymphocytes and HIV
binds and signals through CD4 cells and chemokine molecule which
may induces the upregulation of L selectin and Fas
HIV signaled CD4 cells returned to the blood and further to
lymph nodes and axial bne marrow and further leads to the apoptosis
of cells during trans endothelial migration when the secondary
signals are induced through other receptors
The mechanism of CD4 T lymphocytes depletion by HIV are mainly
due to the use of CD4 as its primary receptors and the signaling
induced through this receptors on resting T lymphocytes