Question

compare and contrast type i and type iv hypersensitivity as to mechanism, symptoms eliciting factors and allergen

Answer 1

Answer:

Compare and contrast type I and type IV hypersensitivity

Type I hypersensitivity	Type IV hypersensitivity
1.This is IgE -mediated hypersensitivity.	1.This is cell mediated hypersensitivity.
2.Antigen induces cross linking of IgE bound to the mast cells and basophils.	2.There is sensitization of TH1 cells .
3.Basophils and mast cells releases vasoactive mediators.	3.Th1 cells releases cytokines that activate Tc cells or macrophages that mediate direct cellular damage.
4.Typical manifestations are systemic anaphylaxis and localised anaphylaxis such as hey fever, asthma, hives, food allergiesand eczema.	4.Typical manifestations include contact dermitatis, tubercular lesions and graft rejection.

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