Question

A. Describe in detail the mechanism responsible for mast-cell activation during a type I hypersensitivity reaction....

A. Describe in detail the mechanism responsible for mast-cell activation during a type I hypersensitivity reaction.

B.   What are the similarities between the activation of mast cells and NK cells via Fc?RI and Fc?RIII, respectively? Be specific.

C.     What are the differences? Again, be specific.

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Answer #1

Ans a) Type I hypersensitivity or immediate hypersensitivity is an allergic reaction which is caused by re-exposure to a specific type of antigen which is also called as allergen. The infection might take place due to ingestion, inhalation or injection. The mast cells are a type of WBC that comes the myeloid stem cell and it is rich in histamine and heparin. The allergies mediate a IgE signaling that triggers mast cell degranulation. The B-cells are stimulated to produce the IgE antibodies that are specific to an antigen. The IgE antibodies are sensitized and they bind to the receptors on the surface of tissue mast cells and blood basophils. This leads to activation of the mast cells and the allergen forms cross links leading to the anaphylactic degranulation.

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