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What is mast cell sensitization and how does it contribute to Type I hypersensitivity reactions?

What is mast cell sensitization and how does it contribute to Type I hypersensitivity reactions?

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mast cell degranulation are due to IgE antibodies during allergic diseases. mast cell sensitization is binding of IgE to its high affinity IgE receptor on mast cell surface which allows the development of clinical allergy.

type 1 hypersensitivity has antibody is IgE rather than  IgA, IgG, or IgM that is present in normal infectious immune response . The IgE antibodies attaches to FcεRI receptors during sensitization that is present on the surface of tissue mast cells and blood basophils which leads to mast cell activation.

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