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Yeast has a multivalent adapter protein called KSR. It has binding sites for MAPK, MAPKK, and...

Yeast has a multivalent adapter protein called KSR. It has binding sites for MAPK, MAPKK, and MAPKKK proteins. Give two reasons why this complex facilitates the signaling mechanism these enzymes are involved in.

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Answer #1

KSR is an example of multivalent protein scaffold that regulate key signalling pathways. This adaptor protein can interact with multiple proteins in the signal cascade thereby helping the pathway to be localised in specific cellular components.

KSR is a positive regulator of the pathway and it ca bind to all the three map kinases involved in the signalling.

This protein complex is localised to the plasma membrane so that the components can be assembled and localised to the plasma membrane.

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