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Myc is a potent oncogenic protein that has many effects in the cell. Answer the following...

Myc is a potent oncogenic protein that has many effects in the cell. Answer the following questions regarding Myc. Myc is an example of a bHIH protein, what does this mean? Give an example of two other bHIH proteins. How do these bHIH proteins affect cancer deveolpment? Be specific with regards to which molecules are being turned on/off. Mention where in the cell cycle the effects takes place and the effect it has on cell differentiation?

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Answer #1

Answer 1) BHLH class of protein contain basic helix-loop-helix motifs as structural component which interacts with DNA.

Answer 2) The other two example of BHLH proteins include MyoD protein and Hypoxia induced factor (HIF).

Answer 3) BHLH class of proteins contains basic helix-loop-helix structural motifs through which they bind to the DNA and act as transcription factor regulating the transcription of cancer related genes.

Answer 4) BHLH protein being as transcription regulator specifically regulate the transcriptional suppression of tumor inducing genes/ growth inducing genes acting as tumor suppresser.

Answer 5&6) Since BHL proteins suppress the expression of growth related genes, they act in the G1 phase of the cell cycle blocking the cell in G1 phase, thus acting as tumor suppresser.

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