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All GPCRs contain 7 transmembrane domains. What would a hydropathy plot of a GPCR look like?...

All GPCRs contain 7 transmembrane domains. What would a hydropathy plot of a GPCR look like? Draw a hypothetical hydropathy plot (does not have to be exact) that you think represents a "typical" GPCR and upload a photo of your drawing.

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Answer #1

GPCR has 7 transmembrane domain. The plasma membrane is amphipathic in nature. It has a hydrophilic head and a hydrophobic tail embedded inside the plasma membrane. Transmembrane domain passes through the hydrophobic tail group. To stabilize in the transmembrane domain, so the amino acid present in it should be hydrophobic.

Since there is a seven-transmembrane domain, so in the hydropathy plot, we should get seven areas in the hydrophobic region.

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