For each of these 3 channels, describe where they are found, how they work, and the role they play in physiology: 1) the cardiac ryanodine channel, 2) the voltage gated calcium channel on neurons, and 3) the dihydropyridine ryanodine channel.
Type of Channel: | Cardiac Ryanodine | Dihydropyridine Ryanodine | Voltage Gated Ca+2 in neuron |
-Also known as cardiac Ca+2 release channel. -It is an intracellular Ca+2 channel. |
-A voltage dependent channel. -It is also a Ca+2 channel. |
-Voltage dependent Ca+2 channel. |
|
Found in | Cardiac(heart) muscle cell's membrane | T-tubules of Skeletal muscle | Neuron |
Working | A small amount of Ca+2 in cytosol near channel will cause it to release Ca+2 from sarcoplasmic reticulum. | Work at depolarised membrane potential or due to action potentail | Open at depolarized membrane potential. |
Physiological Role | Cardiac contraction | Skeleton muscle contraction | Excitation of Neuron,which help in release of hormones and neurotransmitter. |
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