Question

2. You have a muscular dysfunction that lacks T-tubules. How might this affect muscle contraction?

3. You have a muscular dysfunction that lacks sarcoplasmic reticulum. How might this affect muscle contraction?

4. You have a muscular dysfunction that lacks voltage-gated channels. How might this affect muscle contraction?

5. You have a muscular dysfunction that lacks chemically-gated channels. How might this affect muscle contraction?

Answer 1

2. lacking of T-tubules would lead to the much weaker contraction or would stop the muscle contraction because t-tubules invloves in the conduction of action potential deeper into the cell from cell surface (sarcolemma).

3. sarcoplasmic reticulum store Ca++ ions. depolarization of cell membrane including t-tubule enable the release of ca++ ion which initiate contraction . stored ca++ binds to troponin and as long as ATP is available , muscle fibres becomes shorten and shorten.

4. lacking of voltage gated channels would lead into stoppage of muscle contraction because voltage gated channels are responsible for depolarization of sarcolemma to release the stored ca++ ions which ultimately responsible for the initiation of the muscle contraction.