Question

#1 Engineer a neuron that has a positive resting potential but propagates a signal through its axon. You can design (1) your own ion pump and determine directionality of the pump (2) design voltage gated channels. You can use hypothetical negative N1-, N2-, etc.. and positive ions P1+, P2+, etc…

#2 Describe 3 channel related diseases; how does the mutation affects the function of the channel and what are the implications? What are the clinical symptoms exhibited by the affected individuals? (~ one paragraph for each condition)

Answer 1

Answer #1-

Here is the hypothetical neuron figure in which P and N are positive and negative charges. Inside the neuron, a net positive charge is present as the hypothetical resting potential. The nucleus and cellular organelles are hypothetically designed. This neuron can activate through a positive action potential. We can assume the resting potential of the neuron is +25. The direction of pump is from outside to inside for negative ions and inside to outside for positive ions.

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