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How Hunchback and Knirps control the expression of eve stripe 3 and 4. How the stripe...

How Hunchback and Knirps control the expression of eve stripe 3 and 4. How the stripe 3 enhancer differs from stripe 4 enhancer.??

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In order to compare dual-regulation and Clyde-Corado mechanisms (in Drosophila embryo), variable Hunchback and Knirps binding constants were analyzed in eve stripes 3 and stripe 4 enhancers. It was observed that the predicted balance between the Hunchback and the Knirps repression activities was almost similar for the dual-regulation and the Clyde-Corado models, that is, stronger is the repression of stripe 4 by Hunchback and stronger is the repression of stripe 3 by Knirps.

Stripe 3 enhancer differs from Stripe 4 enhancer in that stripe 3 is controlled by 5' regulatory region; while stripe 4 is controlled by 3' regulatory region.

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