Question

The secretion proteins have to be folded correctly to get out of the ER. However, proteins...

The secretion proteins have to be folded correctly to get out of the ER. However, proteins that do not fold properly in ER undergo proteosomal destruction. How is it determined that proteins will be destroyed in this way?

Science   Biology   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

Proteosomal destruction or degradation is achieved in the cell by special protein complexes called proteasomes. The proteasomes break the protein molecules by hydrolyzing the peptide bonds. The proteasomes attach to the protein molecule that has to be destroyed, by an ATP dependent process that involves three enzymes.

Proteins are marked for destruction when ubiquitin [Ub] attaches to the amino group of the side chain of a lysine residue with the help of enzymes called ubiquitin ligases. Additional Ub are then added to form a multiubiquitin chain. These poly-ubiquinated proteins are recognized and degraded by the proteasomes.

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
Since you have been home with your family for months and are excited to get out...
Since you have been home with your family for months and are excited to get out to resume your previous level of activity, you and your mom decide that you want to return to your favorite activity; mother/daughter Friday night basketball games. However, since your mom has been putting in long hours working in her home office, she states she can’t resume these weekly games until she gets back into shape. she also states since working from home she has...
We have all wondered how many licks it takes to get to the Tootsie Roll Center...
We have all wondered how many licks it takes to get to the Tootsie Roll Center of the Tootsie Pop, but have you ever heard of this urban legend? “If you get a wrapper with a Native American shooting a star, and take the wrapper to the store where you bought, they will give you a free Tootsie Pop!” The Tootsie Roll Company has never actually given free candy for finding a full image of the Native American shooting a...
Post a response (2-4 sentences each). You can start a discussion by pointing out additional reasons...
Post a response (2-4 sentences each). You can start a discussion by pointing out additional reasons why you think this source is or is not credible. You can also suggest ways in which the site could be improved (is there information or are there sources they could have added? Are there different messages that would be more appropriate?). Write at least 1 response-post for each of the THREE “Part 1” posts you read (you will need at least 3 responses...
4. A negative account that is four years old is being reported incorrectly in your client’s...
4. A negative account that is four years old is being reported incorrectly in your client’s credit report. This account shows that in the past, it was delinquent six times. How should you dispute this account? Determined how this particular account affects your client’s credit score before you dispute it. Because this account could be helping your client’s credit score. Dispute the inaccurately reported account to have it corrected. Do not dispute this account because you need at least one...
Re word this reflection essay and include more studies on creativity in it. What have I...
Re word this reflection essay and include more studies on creativity in it. What have I Learned? I have learned how to use my brain better, to organize my thinking process in a way to facilitate my perceptions, creativity and innovative thinking methods in a more effective manner. I learned many ideas and findings on how human brain function. For example, according to Tony Buzan, the brain thinks in two ways: association or explosion method. I learned that to change...
SCENARIO : OPIOID WITHDRAWL OUTGOING NURSE : So we have an Evet Ogam. She is a...
SCENARIO : OPIOID WITHDRAWL OUTGOING NURSE : So we have an Evet Ogam. She is a 34-year-old female brought in by ambulance, last night at 1800 for a heroin overdose. She was given 2 doses of naloxone, 2mg each dose. She vomited twice following the naloxone. Following stabilization in the ER, she has been brought up to our floor for monitoring. Pt is allergic to aspirin and has a history of back surgery in 2012, Pt has been admitted twice...
Presented below are five scenarios where ethical violations may have occurred. The student should assess each...
Presented below are five scenarios where ethical violations may have occurred. The student should assess each scenario relative to whether it violates one or more of the following "ethical norms," or none at all. The norms, plus the “null hypothesis,” are: Organizational norms (O), which consist of workplace rules/expectations (e.g., be on time, don’t shirk your work, follow the patrol guide). Professional norms (P), which are rules binding on members of one or another profession, (e.g., doctors must "do no...
Problem-Solving Case: Motivating Employees at Nucor Corporation Today Nucor Corporation is the largest producer of steel...
Problem-Solving Case: Motivating Employees at Nucor Corporation Today Nucor Corporation is the largest producer of steel in the United States, so it is hard to believe it was once an underdog in a struggling industry. What has set the company apart is a focus on moti- vating and empowering employees. The employee focus is illustrated by the custom of printing each individual’s name on the cover of Nucor’s annual report. But the concern for employees is much more practical and...
Case Study 11.1 – TATA’S HANDLING OF THE MUMBAI TERRORIST ATTACKS Tata, a global group of...
Case Study 11.1 – TATA’S HANDLING OF THE MUMBAI TERRORIST ATTACKS Tata, a global group of companies headquartered in India, operates in seven busi­ness sectors: communications and information technology, engineering, materials, services, energy, consumer products and chemicals. The group operates in more than 80 countries across six continents, with 58 per cent of its revenues coming from business outside of India. Well-known companies within the group include Tata Steel, Tata Motors, Tata Consultancy services, Tata Tea and Taj Hotels. Whilst...
Write a Python 3 program called “parse.py” using the template for a Python program that we...
Write a Python 3 program called “parse.py” using the template for a Python program that we covered in this module. Note: Use this mod7.txt input file. Name your output file “output.txt”. Build your program using a main function and at least one other function. Give your input and output file names as command line arguments. Your program will read the input file, and will output the following information to the output file as well as printing it to the screen:...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT