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why a positive relationship between hemoglobin A1C (HbA1C) levels and 2,3-DPG (also known as 2,3-BPG) levels...

why a positive relationship between hemoglobin A1C (HbA1C) levels and 2,3-DPG (also known as 2,3-BPG) levels in the blood of patients with Type 1 diabetes is shown?

Science   Anatomy-And-Physiology   
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Answer #1

The hemoglobin A1C (HbA1C) is the glycosylated form of the hemoglobin. The greater the  blood concentraion of the hemoglobin A1C (HbA1C) significantly decreases the oxygen dissociation velocity.The Type 1 diabetes patient having the increased blood concentraion of the hemoglobin A1C (HbA1) triggers the false high pulse oxygen saturation.Increase in the 2,3-DPG (also known as 2,3-BPG) levels in the blood of patients with Type 1 diabetes increases the oxygen affinity (shift the curve to left ) because it act as a heteroallosteric effector to the hemoglobin.Therefore the hemoglobin A1C (HbA1C) levels and  2,3-DPG (also known as 2,3-BPG) both have positive relationship because both decreases the oxygen dissociation velocity.

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