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Explain quantitativelyor qualitatively why during controlled drug delivery, the rate of drug release has to be...

Explain quantitativelyor qualitatively why during controlled drug delivery, the rate of drug release has to be constant (i.e., the release rate should not be increasedor decreasedover time).

Science   Anatomy-And-Physiology   
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Answer #1

With the aim of prevention of dose dumping, and in order to maintain the release of drug at a desired rate, extended release dosage form is used. In order to assess the effect of extended release dosage form, the cumulative percentage of drug released from an extended release dosage form at different time interval is evaluated for in vitro drug release. The aim is to deliver the drug a t a constant rate for an extended period of time. This phenomenon decreases dose frequency and has better patient compliance.

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