Question

Poly(D,L Lactide) and Poly (L lactide) are both used in tissue engineering and drug delivery. a)...

Poly(D,L Lactide) and Poly (L lactide) are both used in tissue engineering and drug delivery.

a) Which polymer is more crystalline and why?

b) If you make a drug release device out of these polymers which device will (i) degrade faster and (ii) release drug faster. Explain?Poly(D,L Lactide) and Poly (L lactide) are both used in tissue engineering and drug delivery. Which polymer is more crystalline and why?

c) If you make a drug release device out of these polymers which device will (i) degrade faster and (ii) release drug faster. Explain?

Science   Chemistry   
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Answer #1

a. Poly(D,L Lactide) also known as PDLA is amorphous in nature, whereas Poly (L lactide) also known as PLLA is more crystalline. The degree of crystallinity, and hence many important properties, is largely controlled by the ratio of D to L enantiomers used. Higher the D, lower the crystalinity.

b. Biodegradation of PDLA is faster than for PLLA due to the higher crystallinity of PLLA. Hence, PDLA will degrade faster. But PLLA will release drug faster due to it's structured crystalline structure.

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